BRUSH UP YOUR NMR, 4-(3,5-Dichloropyridin-4-yl)morpholine

3,5-Dichloro-4-morpholinopyridine

Preparation of 4-(3,5-Dichloropyridin-4-yl)morpholine (5).(Pichowicz, M.; Crumpler, S.; McDonald, E.; Blagg, J. Tetrahedron 2010, 66, 2398, DOI: 10.1016/j.tet.2010.01.101)

 

 5 as a light-orange solid.

 

1H NMR (CDCl3, 400 MHz): δ = 8.35 (2H, s), 3.84 (4H, m), 3.37 (4H, m);

 

13C NMR (CDCl3, 101 MHz): δ = 150.8, 149.3, 128.4, 67.4, 50.4;

 

HRMS–ESI+: m/z [M + H]+ calcd for C9H11Cl2N2O+: 233.02429; found: 233.02446.

 

 

 

Org. Process Res. Dev., Article ASAP

DOI: 10.1021/acs.oprd.8b00009

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Clc2cncc(Cl)c2N1CCOCC1

Methionine sulfoxide

v

Methionine sulfoxide (2a). 1H NMR (D2O, 400 MHz): δ = 3.79 (m, 1H), 2.81-3.08 (m, 2H), 2.66 (s, 3H), 2.23 (m, 2H) ppm. The NMR data matched the data obtained for commercial methionine sulfoxide. ESI HRMS m/z C5H12O3NS [M+H]+ : calcd 166.05324. Found: 166.05330

Scalable Photocatalytic Oxidation of Methionine under Continuous-Flow Conditions

Noémie Emmanuel†, Carlos Mendoza‡, Marc Winter§, Clemens R. Horn§, Alessandra Vizza§, Laurent Dreesen*∥, Benoît Heinrichs*‡, and Jean-Christophe M. Monbaliu*† 

†Center for Integrated Technology and Organic Synthesis, Department of Chemistry, ‡Nanomaterials, Catalysis & Electrochemistry - NCE, Department of Chemical Engineering, ∥Biophotonics, Department of Physics, University of Liège, B-4000 Liège (Sart Tilman), Belgium

§ Corning Reactor Technologies, Corning SAS, 7 bis Avenue de Valvins, CS 70156 Samois sur Seine, 77215 Avon Cedex, France

Org. Process Res. Dev., Article ASAP

DOI: 10.1021/acs.oprd.7b00212

 

*E-mail: jc.monbaliu@ulg.ac.be., *E-mail: Laurent.Dreesen@ulg.ac.be., *E-mail: b.heinrichs@ulg.ac.be.

Highly efficient and chemoselective singlet oxygen oxidation of unprotected methionine was performed in water using a continuous mesofluidic reactor. Sustainable process engineering and conditions were combined to maximize process efficiency and atom economy, with virtually no waste generation and safe operating conditions. Three water-soluble metal-free photosensitizers [Rose Bengal, Methylene Blue, and tetrakis(4-carboxyphenyl)porphyrin] were assessed. The best results were obtained with Rose Bengal (0.1 mol %) at room temperature under white light irradiation and a slight excess of oxygen. Process and reaction parameters were monitored in real-time with in-line NMR. Other classical organic substrates (α-terpinene and citronellol) were oxidized under similar conditions with excellent performances.

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ORGANIC SPECTROSCOPY SOLVED PROBLEM-CAMPHOR

SOLVED PROBLEM-CAMPHOR

CAMPHOR, 

SEE ALL AT

https://sites.google.com/site/anthonycrastospectroscopy/1d-solved-problem-camphor



 https://sites.google.com/site/anthonycrastospectroscopy/1d-solved-problem-camphor



 https://sites.google.com/site/anthonycrastospectroscopy/1d-solved-problem-camphor




Take a tour











 Qantab beach in oman
 
 Stephen Rego

 
 


 

 

 


 
 


 

 

 

A lovely day at the beach my sis and I spent at Qantab back in 2006:

(I have a thing for old Mosques).

Yeah, walking on that roof was soooooo not a good idea (I was covered in dust when a section caved in). Alhamdulilah I wasn't hurt at all, and was a little mroe willing to take advice about what is structurally sound and what isn't.

Our fave midnight hang-out ledge. For loosing Ah's fishing rods.

 Other than that, carry on!

Omani architecture

Muscat Fashion Week

enjoying art and eye candy

fabulous food and places to see and be seen

fabulous finds

Castles and Jinn

Omani traditions and superstitions

camping and off-road adventures

desert sunrises

not desert, and not just Salalah

recipes, Omani and inspired by Oman

forts crumbling into ruins and castles in the clouds

Mountain villages

coastal villages

the simple life

the simple life

and a couple of camels of course!

and a couple of camels of course!.............http://howtolivelikeanomaniprincess.blogspot.in/2011/06/my-own-photos-qantab-beach-2006.html

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